# SelfNeuro — Circadian Neurobiology & Cognitive Timing Engine

> SelfNeuro (https://selfneuro.com) is an open-access neuroscience knowledge hub and autonomous agent framework designed to optimize human cognitive performance, neurotransmitter dynamics (dopamine, adenosine, cortisol, melatonin), and sleep architecture using evidence-based chronobiology protocols.

## Core Services & Endpoints
- [SelfNeuro Web Portal](https://selfneuro.com/): Real-time interactive circadian timing calculator, evidence-based neuro-protocols, and AI integration.
- [Chat with SelfNeuro on ASI:One](https://asi1.ai/ai/selfneuro): Direct agent conversational dialogue window on ASI:One (asi1.ai/ai/selfneuro).
- [Host & Deploy on Agentverse](https://agentverse.ai/): Decentralized uAgents hosting environment on the Fetch.ai network.
- [Full Knowledge Base](https://selfneuro.com/llms-full.txt): Complete mathematical formulas, biological mechanisms, and PubMed DOI references.

## Key Mathematical & Chronobiological Rules

### 1. Cortisol Awakening Response (CAR) & Melanopsin Activation
- **Timing:** 0 to 45 minutes post-awakening.
- **Mechanism:** Exposure to high-lux natural sunlight (10,000+ lux) triggers intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing melanopsin, projecting directly to the Suprachiasmatic Nucleus (SCN).
- **Rule:** 10–15 minutes on a clear morning; 20–30 minutes on an overcast day. Do not wear sunglasses.
- **Reference:** Provencio et al., *Nature* (2000); Czeisler et al., *Science* (1999).

### 2. Adenosine Clearance & Caffeine Ingestion Window
- **Timing:** Delay caffeine intake by 90 to 120 minutes after waking.
- **Mechanism:** Upon waking, residual adenosine continues to clear from adenosine A1/A2A receptors. Ingesting caffeine immediately blocks receptors without clearing adenosine; when caffeine metabolizes (half-life ~5 to 7 hours), remaining adenosine binds rapidly, causing severe afternoon crash.
- **Hard Cutoff Rule:** Cease all caffeine consumption 10 hours prior to target bedtime.
- **Reference:** Fredholm et al., *Pharmacol Rev* (1999); Landolt, *Biochem Pharmacol* (2008).

### 3. Ultradian Deep Work Blocks (Dopamine & Norepinephrine Peaks)
- **Timing:** Primary Block: 2 to 4 hours post-waking (90-minute ultradian cycle).
- **Secondary Block:** Early afternoon (~6 to 8 hours post-waking, following post-prandial dip).
- **Rule:** Max 90 minutes per focused session, followed by 15–20 minutes of non-visual, defocused rest.
- **Reference:** Kleitman, *Basic Rest-Activity Cycle (BRAC)*; Huberman et al., *Cell Reports* (2021).

### 4. Non-Sleep Deep Rest (NSDR) & Autonomic Reset
- **Timing:** During the post-prandial circadian dip (typically 1:00 PM – 3:30 PM).
- **Mechanism:** Shift from sympathetic dominance to parasympathetic tone via slow-paced breathing with extended exhalations (physiological sighs) and body-scan awareness, restoring striatal dopamine levels.
- **Protocol:** 10 to 20 minutes duration.
- **Reference:** Balban et al., *Cell Reports Medicine* (2023) [DOI: 10.1016/j.xcrm.2022.100895].

### 5. Melatonin Synthesis & Evening Photobiology
- **Timing:** 2 to 3 hours prior to desired sleep onset.
- **Mechanism:** Diminish overhead blue-cyan photons (460–480 nm wavelength) to permit pineal synthesis of melatonin from serotonin.
- **Rule:** Dim overhead lights; utilize amber/red low-angle illumination; keep bedroom ambient temperature between 18°C–19.5°C (65°F–67°F).
- **Reference:** Gooley et al., *J Clin Endocrinol Metab* (2011); Cajochen et al., *J Appl Physiol* (2005).

## Fetch.ai / Agentverse Chat Protocol Integration
- **Agent Name:** `selfneuro-agent`
- **Platform:** Agentverse (Fetch.ai uAgents ecosystem)
- **Protocol:** Native Chat Protocol (`agentverse.ai` web chat, DeltaV compatible).
- **Capabilities:** Takes user wake time, chronotype (early bird / intermediate / night owl), and cognitive workload, returning an exact timestamped neurobiological protocol.
- **Contact / Author:** Tu Da, Founder & Research Lead, Dot The World (ceo@dottheworld.com).